366 - Fat may secretly fuel Alzheimer’s, new research finds
ScienceDaily  October 3, 2025 Houston Methodist https://www.sciencedaily.com/releases/2025/10/251003033915.htm .

New research from Houston Methodist reveals how obesity may directly drive Alzheimer’s disease. Scientists discovered that tiny messengers released by fat tissue, called extracellular vesicles, can carry harmful signals that accelerate the buildup of amyloid-β plaques in the brain. These vesicles even cross the blood–brain barrier, making them powerful but dangerous connectors between body fat and brain health.

The findings were published on October 2 in Alzheimer's & Dementia: The Journal of the Alzheimer's Association under the title "Decoding Adipose-Brain Crosstalk: Distinct Lipid Cargo in Human Adipose-Derived Extracellular Vesicles Modulates Amyloid Aggregation in Alzheimer's Disease." The study explores how obesity, which affects about 40% of Americans, may contribute to the neurodegenerative disorder that currently impacts more than 7 million people in the U.S.

The researchers discovered that these vesicles carry different lipid molecules in people with obesity compared to lean individuals. Those differences appear to influence how quickly amyloid-β proteins clump together in the brain. Using both mouse models and samples of human body fat, the scientists examined how these membrane-bound particles move through the body and affect brain processes. Remarkably, these tiny messengers can even cross the blood-brain barrier, enabling direct communication between fat tissue and the brain.

Amen dear Sister Dorine!  It is interesting how Jesus led the woman at the well to surrender her heart to God. As we do the same, we will also receive the same joy that filled Jesus as she drank of the Living Water.


     Here is declared the same truth that Jesus had revealed to Nicodemus when He said, "Except a man be born from above, he cannot see the kingdom of God." John 3:3, margin. Not by seeking a holy mountain or a sacred temple are men brought into communion with heaven. Religion is not to be confined to external forms and ceremonies. The religion that comes from God is the only religion that will lead to God. In order to serve Him aright, we must be born of the divine Spirit. This will purify the heart and renew the mind, giving us a new capacity for knowing and loving God. It will give us a willing obedience to all His requirements. This is true worship. It is the fruit of the working of the Holy Spirit. By the Spirit every sincere prayer is indited, and such prayer is acceptable to God. Wherever a soul reaches out after God, there the Spirit's working is manifest, and God will reveal Himself to that soul. For such worshipers He is seeking. He waits to receive them, and to make them His sons and daughters
     As the woman talked with Jesus, she was impressed with His words. Never had she heard such sentiments from the priests of her own people or from the Jews. As the past of her life had been spread out before her, she had been made sensible of her great want. She realized her soul thirst, which the waters of the well of Sychar could never satisfy. Nothing that had hitherto come in contact with her had so awakened her to a higher need. Jesus had convinced her that He read the secrets of her life; yet she felt that He was her friend, pitying and loving her. While the very purity of His presence condemned her sin, He had spoken no word of denunciation, but had told her of His grace, that could renew the soul. She began to have some conviction of His character. The question arose in her mind, Might not this be the long-looked-for Messiah? She said to Him, "I know that Messias cometh, which is called Christ: when He is come, He will tell us all things." Jesus answered, "I that speak unto thee am He."   
     As the woman heard these words, faith sprang up in her heart. She accepted the wonderful announcement from the lips of the divine Teacher.
     This woman was in an appreciative state of mind. She was ready to receive the noblest revelation; for she was interested in the Scriptures, and the Holy Spirit had been preparing her mind to receive more light. She had studied the Old Testament promise, "The Lord thy God will raise up unto thee a Prophet from the midst of thee, of thy brethren, like unto me; unto Him ye shall hearken." Deuteronomy 18:15. She longed to understand this prophecy. Light was already flashing into her mind. The water of life, the spiritual life which Christ gives to every thirsty soul, had begun to spring up in her heart. The Spirit of the Lord was working with her......That which had been withheld from the Jews, and which the disciples were afterward enjoined to keep secret, was revealed to her. Jesus saw that she would make use of her knowledge in bringing others to share His grace......As His words to the woman had aroused her conscience, Jesus rejoiced. He saw her drinking of the water of life, and His own hunger and thirst were satisfied. The accomplishment of the mission which He had left heaven to perform strengthened the Saviour for His labor, and lifted Him above the necessities of humanity. To minister to a soul hungering and thirsting for the truth was more grateful to Him than eating or drinking. It was a comfort, a refreshment, to Him. Benevolence was the life of His soul.     

     Looking in faith to the Redeemer, John had risen to the height of self-abnegation. He sought not to attract men to himself, but to lift their thoughts higher and still higher, until they should rest upon the Lamb of God. He himself had been only a voice, a cry in the wilderness. Now with joy he accepted silence and obscurity, that the eyes of all might be turned to the Light of life.

Amen sister Dorine.

This paragraph shows how humble John's spirit was, and ours should be also, John knew his role was to prepare the way of the Lord, and he did so, pointing all to Christ and his mission as the Missiah, may our lives be the same, with joy point those around us to Christ, and justification by faith, that they may if God's kingdom, as coworkers for God.

Jesus continued: “That which is born of the flesh is flesh; and that which is born of the Spirit is spirit.” By nature the heart is evil, and “who can bring a clean thing out of an unclean? not one.” Job 14:4. No human invention can find a remedy for the sinning soul. “The carnal mind is enmity against God: for it is not subject to the law of God, neither indeed can be.” “Out of the heart proceed evil thoughts, murders, adulteries, fornications, thefts, false witness, blasphemies.” Romans 8:7; Matthew 15:19. The fountain of the heart must be purified before the streams can become pure. He who is trying to reach heaven by his own works in keeping the law is attempting an impossibility. There is no safety for one who has merely a legal religion, a form of godliness. The Christian’s life is not a modification or improvement of the old, but a transformation of nature. There is a death to self and sin, and a new life altogether. This change can be brought about only by the effectual working of the Holy Spirit.

Amen brother Richard.

I was also struck by this paragraph; I have highlighted the truth I found enlightening here. When we surrender ourselves to God, he does not wash our robes, he removes them and tosses them away and puts a brand-new robe of righteousness on us. Jesus through faith covers us with this brand-new robe, the old life is done away with, and Jesus transforms us into a new person, He completes the work He has begun in us. Then we complete the work He has given to us, planting seeds into others, the Holy Spirit convicts, God's work of transformation in the done in this soul. Thus, God's plan of multiplication works.