By American Academy of Neurology April 9, 2025
https://scitechdaily.com/eight-drinks-a-week-heres-what-that-does-to-your-brain-over-time/ The research was based on brain autopsies from 1,781 individuals, who had an average age of 75 at the time of death.
Researchers then divided the participants into four groups:
965 people who never drank,
319 moderate drinkers who had seven or fewer drinks per week;
129 heavy drinkers who had eight or more drinks per week; and
368 former heavy drinkers.
Researchers defined one drink as having 14 grams of alcohol, which is about 350 milliliters (ml) of beer, 150 ml of wine or 45 ml of distilled spirits.
After adjusting for factors that could affect brain health such as age at death, smoking, and physical activity, heavy drinkers had 133% higher odds of having vascular brain lesions compared to those who never drank, former heavy drinkers had 89% higher odds, and moderate drinkers, 60%.
Tau Tangles and Cognitive Impacts
Researchers also found heavy and former heavy drinkers had higher odds of developing tau tangles, a biomarker associated with Alzheimer’s disease, with 41% and 31% higher odds, respectively.
Former heavy drinking was associated with a lower brain mass ratio, a smaller proportion of brain mass compared to body mass, and worse cognitive abilities.