323 - Cold plunges improve your health by literally changing your cells
Sanjana Gajbhiye Earth.com 29 March 2025
https://www.earth.com/news/cold-plunges-may-keep-you-feeling-alive-and-healthy-longer/A team of researchers at the University of Ottawa has taken a closer look. Their work didn’t just explore how our bodies handle cold on the outside. It examined what happens on a much deeper level: inside your cells.
The Human and Environmental Physiology Research Unit conducted a tightly controlled experiment with ten healthy young men.
Over seven days, each participant immersed himself in 14°C (57.2°F) water for one hour per day. Blood samples were drawn before and after the cold-water sessions on days 1, 4, and 7.
The aim wasn’t to measure surface-level outcomes like muscle soreness. Instead, the team analyzed peripheral blood mononuclear cells to examine cellular stress, recovery, and resilience.
They focused on autophagy (the body’s way of cleaning out damaged components) and apoptosis (programmed cell death).
“Our findings indicate that repeated cold exposure significantly improves autophagic function, a critical cellular protective mechanism,” said Professor Kenny.
“This enhancement allows cells to better manage stress and could have important implications for health and longevity.”
On the first day, the researchers found clear signs of stress. Cells showed an increase in proteins like p62, which typically accumulate when autophagy is disrupted. ......
This meant that initially, the cold exposure was overwhelming the cells. The natural repair systems weren’t strong enough to counteract the damage. But that would begin to change by day four.
Day seven marked a significant change. LC3-II rose substantially, showing robust autophagic activity. p62 dropped below baseline.
By day seven, ....... The body was becoming more efficient at conserving heat without relying on rapid muscle contractions [shivering].
This study presents a strong case for integrating safe, structured cold exposure into wellness routines.
Seven days of one-hour immersion changed how cells handled stress, repaired themselves, and avoided damage. It’s one of the first studies to show these changes at a molecular level in humans.