Health > Healthful Living

290 - Compound in Ginger Fights Irritable Bowel Disease Naturally

(1/1)

Curt:
290 - Scientists Discover Compound in Ginger That Fights IBD Naturally

By University of Toronto February 24, 2025

​ https://scitechdaily.com/scientists-discover-compound-in-ginger-that-fights-ibd-naturally/

Researchers at the University of Toronto discovered that furanodienone (FDN), a compound in ginger, binds to the pregnane X receptor (PXR) to reduce colon inflammation in inflammatory bowel disease (IBD). This discovery highlights FDN’s potential as a natural, cost-effective treatment that avoids the immune suppression and liver side effects of current therapies.

By screening ginger’s chemical components for interactions with receptors associated with IBD, the researchers discovered that FDN strongly binds to the pregnane X receptor (PXR). This interaction helps reduce colon inflammation by enhancing PXR’s ability to suppress the production of pro-inflammatory cytokines. Although FDN has been known for decades, its biological functions and molecular targets had remained unclear until now.

“We found that we could reduce inflammation in the colons of mice through oral injections of FDN,” said Jiabao Liu, research associate at U of T’s Donnelly Centre for Cellular and Biomolecular Research.

“Our discovery of FDN’s target nuclear receptor highlights the potential of complementary and integrative medicine for IBD treatment. We believe natural products may be able to regulate nuclear receptors with more precision than synthetic compounds, which could lead to alternative therapeutics that are cost-effective and widely accessible.”

rahab:
Helps nagging joints too  ;D

Navigation

[0] Message Index