282 - Do Prostate Biopsies Promote the Spread of Cancer Cells?
Medscape UK Maria Weib 25 October 2024
https://www.medscape.co.uk/viewarticle/do-prostate-biopsies-promote-spread-cancer-cells-2024a1000jj8?ecd=mkm_ret_241117_mscpmrk_onc_prostate_etid7003561&uac=305958HN&impID=7003561&sso=trueFor men aged 50-69 years who underwent a one-time prostate-specific antigen (PSA) screening for prostate cancer, a lower prostate cancer-specific mortality was observed after 15 years of follow-up, but the reduction was only slight. Could this be due to the dissemination of cancer cells through prostate biopsies?
Needle Biopsy May Seed Tumour Cells: -
Injury to tumour tissue and its surroundings caused by a biopsy needle can activate macrophages, which promote angiogenesis and tumour cell dissemination.
Circulating Cancer Cells Detectable After Biopsy:
Immediately after a needle biopsy of the prostate, circulating prostate cancer cells can be detected, and the level of increase correlates with shorter progression-free survival.
A study of 569 patients with prostate cancer revealed that 70% had disseminated tumour cells in the bone marrow even before undergoing radical prostatectomy. This finding persisted in 57% of the affected patients
20 months after prostatectomy, and it was associated with a nearly sevenfold increase in the risk of recurrence.